Sertraline

**Sertraline**
Clinical data
Trade names	Zoloft (左洛復)，彼邁樂， Lustral等
AHFS/Drugs.com	Monograph
MedlinePlus	a697048
Pregnancy; category	AU: C ; US: C (Risk not ruled out) ; ;
Routes of; administration	口服
ATC code	N06AB06 (WHO) ;
Legal status
Legal status	AU: S4 (Prescription only) ; UK: POM (Prescription only) ; US: ℞-only ; In general: ℞ (Prescription only);
Pharmacokinetic data
Bioavailability	44%
Protein binding	98.5%
Metabolism	肝臟
Elimination half-life	~23-26點鐘 (雞發性的代謝產物Norsertraline是66點鐘)
Excretion	尿譯
Identifiers
	IUPAC name (1S,4S)-4-(3,4-dichlorophenyl)-N-methyl-1,2,3,4-tetrahydronaphthalen-1-amine;
CAS Number	79617-96-2 ;
PubChem CID	68617;
DrugBank	DB01104 ;
ChemSpider	61881 ;
UNII	QUC7NX6WMB;
KEGG	D02360 ;
ChEBI	CHEBI:9123 ;
ChEMBL	CHEMBL809 ;
Chemical and physical data
Formula	C17H17Cl2N
Molar mass	306.229 g/mol
3D model (JSmol)	Interactive image;
	SMILES ClC1=CC=C([C@H ]2C3=C([C@H ](CC2)NC)C=CC=C3)C=C1Cl;
	InChI InChI=1S/C17H17Cl2N/c1-20-17-9-7-12(13-4-2-3-5-14(13)17)11-6-8-15(18)16(19)10-11/h2-6,8,10,12,17,20H,7,9H2,1H3/t12-,17-/m0/s1 ; Key:VGKDLMBJGBXTGI-SJCJKPOMSA-N ;
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Sertraline嘛 (mā)叫 (kiò)做 (chò)舍曲林 (Sià-khiok-lîm) (舍曲林) ，抑 (ia̍h)有 (ū)Zoloft的 (ê)商品 (siong-phín)名 (miâ)，是 (sī)一 (chi̍t)種 (chióng)選的勝 (sóan-te̍k-sèng)血稱數 (huih-chheng-sò͘)載攝取 (chài-liap-chhú)億濟制 (ek-chè-chè)類 (lūi)个 (ê)抗 (khòng)億鬱 (ek-ut)藥物 (io̍h-bu̍t)，佇 (tī)1991年 (nî)由 (iû)Pfizer製藥 (chè-io̍h)公司 (kong-su)法明 (hoat-bêng)。

性質 (Sèng-chit)[修改]

Sertraline是白色 (pe̍h-sek)，麻微 (bâ-bui)洋 (iûⁿ)於 (î)水 (chúi)的結晶 (kiat-chiⁿ).

↑ drugs.com drugs。com international Sertraline Page accessed May 11, 2015
↑ Obach RS， Cox LM， Tremaine LM (2005). "Sertraline is metabolized by multiple cytochrome P450 enzymes， monoamine oxidases， and glucuronyl transferases in human: 安怹vitro study". Drug Metab。 Dispos。. 33 (2): 262–70. doi:10.1124/dmd.104.002428. PMID 15547048.
↑ Sertraline FDA Label. http://www.fda.gov/ohrms/dockets/ac/04/briefing/4006b1_06_zoloft-label.pdf
↑ Brunton L， Chabner B， Knollman B。 Goodman and Gilman’s The Pharmacological Basis of Therapeutics， Twelfth Edition。 McGraw Hill Professional; 2010.

[1] rugs.com drugs。com international Sertraline Page accessed May 11, 2015

[pmid15547048-2] Obach RS， Cox LM， Tremaine LM (2005). "Sertraline is metabolized by multiple cytochrome P450 enzymes， monoamine oxidases， and glucuronyl transferases in human: 安怹vitro study". Drug Metab。 Dispos。. 33 (2): 262–70. doi:10.1124/dmd.104.002428. PMID 15547048.

[FDALabel-3] Sertraline FDA Label. http://www.fda.gov/ohrms/dockets/ac/04/briefing/4006b1_06_zoloft-label.pdf

[GG-4] Brunton L， Chabner B， Knollman B。 Goodman and Gilman’s The Pharmacological Basis of Therapeutics， Twelfth Edition。 McGraw Hill Professional; 2010.

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Clinical data


Trade names	Zoloft (左洛復)，彼邁樂， Lustral等^[1]
AHFS/Drugs.com	Monograph
MedlinePlus	a697048
Pregnancy category	AU: C US: C (Risk not ruled out)
Routes of administration	口服
ATC code	N06AB06 (WHO)
Legal status
Legal status	AU: S4 (Prescription only) UK: POM (Prescription only) US: ℞-only In general: ℞ (Prescription only)
Pharmacokinetic data
Bioavailability	44%
Protein binding	98.5%
Metabolism	肝臟^[2]
Elimination half-life	~23-26點鐘 (雞發性的代謝產物Norsertraline是66點鐘)^[3]^[4]
Excretion	尿譯
Identifiers
IUPAC name (1S,4S)-4-(3,4-dichlorophenyl)-N-methyl-1,2,3,4-tetrahydronaphthalen-1-amine
CAS Number	79617-96-2^Y
PubChem CID	68617
DrugBank	DB01104^Y
ChemSpider	61881^Y
UNII	QUC7NX6WMB
KEGG	D02360^Y
ChEBI	CHEBI:9123^Y
ChEMBL	CHEMBL809^Y
Chemical and physical data
Formula	C₁₇H₁₇Cl₂N
Molar mass	306.229 g/mol
3D model (JSmol)	Interactive image
SMILES ClC1=CC=C([C@H ]2C3=C([C@H ](CC2)NC)C=CC=C3)C=C1Cl
InChI InChI=1S/C17H17Cl2N/c1-20-17-9-7-12(13-4-2-3-5-14(13)17)11-6-8-15(18)16(19)10-11/h2-6,8,10,12,17,20H,7,9H2,1H3/t12-,17-/m0/s1^Y Key:VGKDLMBJGBXTGI-SJCJKPOMSA-N^Y
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Sertraline

性質 (Sèng-chit)[修改]

巡覽me-niú

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