Pûi-tōa sè-pau
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| 肥大細胞 (mast cell) | |
|---|---|
 有兩个肥大細胞咧骨髓內底。 | |
| 詳細 | |
| System | 免疫系統 |
| Latin語 | mastocytus |
肥大細胞的
註解 [修改]
- ↑ "labrocytes". Memidex. goân-loē-iông tī 6 November 2018 hőng khó͘-pih. 19 February 2011 khòaⁿ--ê.
- ↑ Ehrlich, Paul (1878). "Beiträge zur Theorie und Praxis der Histologischen Färbung". Leipzig University.
- ↑ da Silva EZ， Jamur MC， Oliver C (2014). "Mast cell function: a new vision of an old cell". J。 Histochem。 Cytochem。. 62 (10): 698–738. doi:10.1369/0022155414545334. PMC 4230976
. PMID 25062998. Mast cells can recognize pathogens through different mechanisms including direct binding of pathogens or their components to PAMP receptors on the mast cell surface， binding of antibody or complement-coated bacteria to complement or immunoglobulin receptors， or recognition of endogenous peptides produced by infected or injured cells (Hofmann and Abraham 2009)。 The pattern of expression of these receptors varies considerably among different mast cell subtypes。 TLRs (1–7 and 9)， NLRs， RLRs， and receptors for complement are accountable for most mast cell innate responses
Vancouver style error: non-Latin character (help) - ↑ Polyzoidis S， Koletsa T， Panagiotidou S， Ashkan K， Theoharides TC (2015). "Mast cells in meningiomas and brain inflammation". J Neuroinflammation. 12 (1): 170. doi:10.1186/s12974-015-0388-3. PMC 4573939 . PMID 26377554.
MCs originate from a bone marrow progenitor and subsequently develop different phenotype characteristics locally in tissues。 Their range of functions is wide and includes participation in allergic reactions， innate and adaptive immunity， inflammation， and autoimmunity [34]。怹the human brain， MCs can be located in various areas， such as the pituitary stalk， the pineal gland， the area postrema， the choroid plexus， thalamus， hypothalamus， and the median eminence [35]。怹the meninges， they are found within the dural layer in association with vessels and terminals of meningeal nociceptors [36]。 MCs have a distinct feature compared to other hematopoietic cells in that they reside in the brain [37]。 MCs contain numerous granules and secrete an abundance of prestored mediators such as corticotropin-releasing hormone (CRH)， neurotensin (NT)， substance P (SP)， tryptase， chymase， vasoactive intestinal peptide (VIP)， vascular endothelial growth factor (VEGF)， TNF， prostaglandins， leukotrienes， and varieties of chemokines and cytokines some of which are known to disrupt the integrity of the blood-brain barrier (BBB) [38–40].
Vancouver style error: non-Latin character (help)
[The] key role of MCs in inflammation [34] and in the disruption of the BBB [41–43] suggests areas of importance for novel therapy research。 Increasing evidence also indicates that MCs participate in neuroinflammation directly [44–46] and through microglia stimulation [47]， contributing都the pathogenesis of such conditions such as headaches， [48] autism [49]， and chronic fatigue syndrome [50]。怹fact， a recent review indicated that peripheral inflammatory stimuli can cause microglia activation [51]， thus possibly involving MCs outside the brain. - ↑ Franco CB, Chen CC, Drukker M, Weissman IL, Galli SJ (2010). "Distinguishing mast cell and granulocyte differentiation at the single-cell level". Cell Stem Cell. 6 (4): 361–8. doi:10.1016/j.stem.2010.02.013. PMC 2852254 . PMID 20362540.
參 閱 [修改]
- Allergy
- Mast cell activation syndrome
- Diamine oxidase
- Granulocyte
- Food intolerance
- Histamine
- Histamine intolerance
- Histamine N-methyltransferase or HNMT
- List of distinct cell types in the adult human body
外部 連結 [修改]
- Mast+cells at the U.S. National Library of Medicine Medical Subject Headings (MeSH)